What is Propofol
Propofol is used for induction and maintenance (in some cases) of anesthesia, having largely replaced sodium thiopental. It can also be administered as part of an anaesthesia maintenance technique called total intravenous anesthesia using either manually-programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion or TCI. Propofol is also used to sedate individuals who are receiving mechanical ventilation but are not undergoing surgery, such as patients in theintensive care unit. In critically ill patients, propofol has been found to be superior to lorazepam both in effectiveness and overall cost.Deferasirox half life and dosage
The half-life of deferasirox is between 8 and 16 hours allowing once a day dosing.How Deferasirox WORKS
Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently eliminated by fecal excretion. Its low molecular weight and high lipophilicity allows the drug to be taken orally unlike deferoxamine which has to be administered by IV route (intravenous infusion). Together with deferiprone, deferasirox seems to be capable of removing iron from cells (cardiac myocytes and hepatocytes) as well as removing iron from the blood.
|Specific rotation||+39.5 to +41.5° |
|State of solution(transmittance)||Clear 98.0% min.|
|Chloride[cl]||0.020% max. |
|Ammonium [NH4]||0.02% max. |
|Heavy metals [Pb]||10ppm max|
|Other amino acids||Chromatographically not detectable|
|Loss on drying||0.20% max. |
|Residue on ignition[sulfated]||0.10% max.|
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